Biomaterial Totally Explained

Everything about Biomaterial totally explained

Introduction

The development of biomaterials isn't a new area of science, having existed for around half a century. The study of biomaterials is called biomaterial science. It is an exciting field of science, having experienced steady and strong growth over its history with companies such as Smith and Nephew investing large amounts of money in new products. Biomaterials science encompasses elements of medicine, biology, chemistry and materials science.

Definition of a biomaterial

While a definition for biomaterials has been difficult to formulate, a widely accepted definition for biomaterials is that:
"A biomaterial is any material, natural or man-made, that comprises whole or part of a living structure or biomedical device which performs, auguments, or replaces a natural function".
A biomaterial is essentially a material that's used and adapted for a medical application. Biomaterials can have a benign function, such as being used for a heart valve, or may be bioactive and used for a more interactive purpose such as hydroxy-apatite coated hip implants (the Furlong Hip, by Joint Replacement Instrumentation Ltd, Sheffield is one such example – such implants are lasting upwards of twenty years). Biomaterials are also used every day in dental applications, surgery, and drug delivery (a construct with impregnated pharmaceutical products can be placed into the body, which permits the prolonged release of a drug over an extended period of time).
The definition of a biomaterial doesn't just include man-made materials which are constructed of metals or ceramics. A biomaterial may also be an autograft, allograft or xenograft used as a transplant material.

Biomaterial Applications

Biomaterials are used in:

Joint replacements
Bone plates
Bone cement
Artificial ligaments and tendons
Dental implants for tooth fixation
Blood vessel prostheses
Heart valves
Skin repair devices
Cochlear replacements
Contact lenses

Biomaterials must be compatible with the body, and there are often issues of biocompatibility which must be resolved before a product can be placed on the market and used in a clinical setting. Because of this, biomaterials are usually subjected to the same requirements of those suffered by new drug therapies. All manufacturing companies are also required to ensure traceability of all of their products so that if a defective product is discovered, others in the same batch may be traced.

Subjects integral to biomaterials science

Toxicology A material shouldn't be toxic, unless specifically engineered to be so (for example “smart” drug delivery systems that target cancer cells and destroy them).

Biocompatibility Biocompatibility is difficult to measure, it's defined in terms of success at a specific task.

Functional Tissue structure and pathobiology Understanding of the anatomy and physiology of the action site is essential for a biomaterial to be effective.

Healing Healing is an essential consideration when using biomaterials. The body may experience what is known as a foreign-body reaction after implementation so immuno-suppression may be required.

Dependence on Specific anatomical sites of implantation It is important, during design, to ensure that the implement will fit complementarily and have a beneficial effect with the specific anatomical area of action.

Mechanical and Performance requirements Biomaterials that have a mechanical operation must perform to certain standards and be able to cope with pressures. It is therefore essential that all biomaterials are well designed and are tested. Biomaterials that are used with a mechanical application, such as hip implants, are usually designed using CAD (Computer Aided Design)which allows all of the directional stresses to be calculated, ensuring maximum product life.

Industrial involvement Companies and researchers push the boundaries and development of science in general, and biomaterials are no exception.

Ethics Ethical considerations are paramount – as are legal considerations and compliance with the law.

Regulation As mentioned above, regulation and records are required to be kept by the product manufacturer for much longer than the product life.Further Information

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